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10-Mercaptomethyl-3-t-butoxycarbonylmethyl-2-oxo-1-azacyclodecane → 10-Mercaptomethyl-2-oxo-1-azacyclodecane-3-acetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 10-Mercaptomethyl-3-t-butoxycarbonylmethyl-2-oxo-1-azacyclodecane | HCID 19930807 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 10-Mercaptomethyl-2-oxo-1-azacyclodecane-3-acetic acid | HCID 19930854 | — |
反応手順
10-Mercaptomethyl-3-t-butoxycarbonylmethyl-2-oxo-1-azacyclodecane (0.21 g, 0.69 mmol) is dissolved in methylene chloride (15 mL). Gaseous hydrogen chloride is bubbled through the solvent for 15 minutes, and then the reaction is sealed and stirred overnight. The solvent is evaporated the next day to give 10-mercaptomethyl-2-oxo-1-azacyclodecane-3-acetic acid, MS: M+1=260.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05426103 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-46950eaab8e34cc2a47f6fa0233b2643 |
| 出典メモ | uspto-grants-1995_06 |