関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Aminobenzoic Acid | HCID 978 | — |
| 反応物 | 4-Chloro-8-(trifluoromethyl)quinoline | HCID 90262 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(8-Trifluoromethyl-4-quinolylamino)benzoic acid | HCID 20520124 | 96.6% |
反応手順
23.16 Grams (0.1 mole) of 4-chloro-8-trifluoromethyl quinoline were dissolved in 22 milliliters of concentrated hydrochloric acid and 150 milliliters of water and the solution was added in a stream to a vigorously stirred solution of 13.7 grams (0.1 mole) of p-aminobenzoic acid in 150 milliliters of water at 60° C. The mixture was heated at 90° C. for 2 hours, cooled, and the solid collected and recrystallized from ethanol to give 32.1 grams (83%) of the title compound as the hydrochloride monohydrate, melting point 262°-265° C.(d).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04357333 |
|---|
| 出典データセット | uspto-grants-1982_11 |
|---|
| ORD ID | ord-5918e2de27dd4cb7ac54e02e54c3aa30 |
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| 出典メモ | uspto-grants-1982_11 |
|---|
