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Hydrogen Bromide → 4-(4-Butyl-1-piperazinyl)phenol monohydrobromide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | 1-Butyl-4-(4-methoxyphenyl)piperazine dihydrochloride | HCID 20519334 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 4-(4-Butyl-1-piperazinyl)phenol monohydrobromide | HCID 20519295 | 81% |
反応手順
A mixture of 12.5 parts of 1-butyl-4-(4-methoxyphenyl)-piperazine dihydrochloride and 150 parts of hydrobromic acid solution 48% in glacial acetic acid is stirred and refluxed overnight. The reaction mixture is evaporated and the residue is triturated in 2-propanone. The product is filtered off and crystallized from water, yielding 13.1 parts (81%) of 4-(4-butyl-1-piperazinyl)phenol monohydrobromide; mp. 281.9° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04358449 |
| 出典データセット | uspto-grants-1982_11 |
| ORD ID | ord-358f6c39dad648a5a9023180cf40bca7 |
| 出典メモ | uspto-grants-1982_11 |