Cyclododecanone → 2-Bromocyclododecanone
反応式
[Br:1]Br.[C:3]1(=[O:15])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1>C(Cl)Cl>[CH2:9]1[CH2:10][CH2:11][CH2:12][CH2:13][CH:14]([Br:1])[C:3](=[O:15])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]1参加物
4
実験手順
An amount of 183.8 gm (1.15 mol) of bromine was added dropwise with refluxing under a nitrogen atmosphere to a well agitated solution comprising 182.3 gm (1 mol) of cyclododecanone in 275 ml of methylene chloride over a period of six hours. Agitation was continued for 15 minutes and approximately one-half of the solvent was distilled off. The solution obtained by this method contained approximately 235 gm of α-bromocyclododecanone (90% yield) and was further reacted directly.
後処理
- temperaturewith refluxing under a nitrogen atmosphere to a well agitated solution
- customof six hours
- distillationapproximately one-half of the solvent was distilled off
- customThe solution obtained by this method
出典と根拠
- ORDレコード
- ord-f329c1a06d6f4685bec4b23169a591ea
- 出典データセット
- uspto-grants-1982_11
- 特許番号
- US04360468
反応ノート
読み込み中…