Hydrochloric Acid → Propranolol Hydrochloride

HRID 2198838ノート

反応式

HRID 2198838 の反応式
[C:1]1([O:11][CH2:12][CH:13]([OH:19])[CH2:14][NH:15][CH:16]([CH3:18])[CH3:17])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[ClH:20]>CCOCC>[ClH:20].[C:1]1([O:11][CH2:12][CH:13]([OH:19])[CH2:14][NH:15][CH:16]([CH3:17])[CH3:18])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 313Hydrochloric Acid2 回HCID 4946Propranolol

生成物 1

HCID 62882Propranolol Hydrochloride

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

1-(isopropyl)-3-azetidinol and α-naphthol were reacted in the same manner as in Example 6 to form 1(-α-naphthoxy)-3-(iso-propylamino)-2-propanol. Then the propanol was dissolved in anhydrous ether and was converted to a hydrochloride by blowing a hydrochloric acid gas into the resulting solution. As a result, 1-(α-naphthoxy)-3-(iso-propylamino)-2-propanol hydrochloride melting at 162°-164° C. was obtained.

出典と根拠

ORDレコード
ord-385090c20a024f9dbb94737f229f1b62
出典データセット
uspto-grants-1982_11
特許番号
US04360464

反応ノート

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