Acetic Acid → 1'-Methylspiro[benzothiazole-2(3H),4'-piperidine]
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[SH:8].[CH3:9][N:10]1[CH2:15][CH2:14][C:13](=O)[CH2:12][CH2:11]1.C(O)(=O)C.C1(C)C=CC=CC=1>O>[CH3:9][N:10]1[CH2:15][CH2:14][C:13]2([NH:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=3[S:8]2)[CH2:12][CH2:11]1参加物
6
実験手順
A mixture of 125.5 g 2-amino-thiophenol, 147 g N-methyl-4-piperidone, 2 ml acetic acid and 400 ml toluene is refluxed with a water separator for 2 hours. The mixture is evaporated in vacuo. The residue is recrystallised from methylene chloride/ether/petroleum ether to give the heading compound, m.p. 135°-140°.
後処理
- customThe mixture is evaporated in vacuo
- customThe residue is recrystallised from methylene chloride/ether/petroleum ether
- customto give the heading compound, m.p. 135°-140°
出典と根拠
- ORDレコード
- ord-b5f81450be074655967b563b4a334c20
- 出典データセット
- uspto-grants-1982_11
- 特許番号
- US04360525
反応ノート
読み込み中…