Ammonia → HCID 20517506、化合物

HRID 2198888ノート

反応式

HRID 2198888 の反応式
[CH2:1]([C:3]([CH2:13][NH:14][CH2:15][CH:16]([OH:18])[CH3:17])([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[CH:6]=1)O)[CH3:2].S(=O)(=O)(O)O.O.N>CCOCC>[CH2:1]([C:3]1([C:5]2[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[CH:6]=2)[O:18][CH:16]([CH3:17])[CH2:15][NH:14][CH2:13]1)[CH3:2]

参加物

6

反応物 4

HCID 222AmmoniaHCID 962WaterHCID 1118Sulfuric AcidHCID 54355367HCID 54355367、化合物

生成物 1

HCID 20517506HCID 20517506、化合物収率 21.9%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

METHOD A The product from Example 15 (1.77 g, 0.007 mole) was treated dropwise at 0° C. with concentrated sulphuric acid (2.3 ml). The resulting green gum was allowed to stand overnight at room temperature and was then treated with 25 ml of crushed ice and after thorough mixing, 50 ml of water. The solution was neutralised with excess ammonia and the solution shaken with ether (2×50 ml). The ether layers were washed, and dried (MgSO4) and evaporated to give 360 mg of the title compound as a 50:50 mixture of diastereoisomers.

後処理

  1. washThe ether layers were washed
  2. dry with materialdried (MgSO4)
  3. customevaporated

出典と根拠

ORDレコード
ord-1d1b7dc4e82d406195fa805c8eb7664d
出典データセット
uspto-grants-1982_11
特許番号
US04360519

反応ノート

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