4-(Dimethylamino)Benzaldehyde → Benzenamine, 4-(4-(3-chlorophenyl)-2,5-dihydro-2,2-dimethyl-5-oxazolyl)-N,N-dimethyl-
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:9]([CH3:12])([CH3:11])[N:10]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:13][N:14]([CH3:23])[C:15]1[CH:22]=[CH:21][C:18]([CH:19]=[O:20])=[CH:17][CH:16]=1>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:19]([C:18]3[CH:21]=[CH:22][C:15]([N:14]([CH3:23])[CH3:13])=[CH:16][CH:17]=3)[O:20][C:9]([CH3:11])([CH3:12])[N:10]=2)[CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
3 g of 3-(m-chlorophenyl)-2,2-dimethyl-2H-azirine and 2.4 g of p-(dimethylamino)benzaldehyde were exposed to light for 2 hours in 350 ml of 1,4-dioxane (with the light source described in Example 2). After removing the solvent in a water-jet vacuum, the residue was chromatographed twice on aluminum oxide (neutral, activity 1), the elution was carried out in both cases with n-hexane/ether (9:1). Crystallization from n-hexane gave 4-(m-chlorophenyl)-5-[p-(dimethylamino)phenyl]-2,2-dimethyl-3-oxazoline which melted at 96°-97° C. after drying for 5 hours at 60° C. and 13 Torr.