反応式
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[CH2:11]([OH:13])[CH3:12]>>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:13][CH2:11][CH3:12])=[O:7])=[CH:4][CH:3]=1参加物
3
実験手順
A mixture containing 35 g of 4-fluorobenzoyl chloride in 50 ml of 100% ethanol is refluxed for 15 minutes. 35 g of the ethyl 4-fluorobenzoate obtained are mixed with 22 g of imidazole and 61 g of potassium carbonate in 35 ml of DMSO. The mixture is heated for 18 hours at 120°-130° C. and 500 ml of iced water are then added. A precipitate forms and the expected product crystallizes from iso ether.
後処理
- temperatureis refluxed for 15 minutes
出典と根拠
- ORDレコード
- ord-43d95d9c07ef43d581eb72b8af369b67
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05728723
関連ノート
読み込み中…