Glycine, N-methyl-, methyl ester, hydrochloride (1:1) → Methyl N-(3-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)-N-methylglycinate

関与物質

反応手順

The title compound was prepared following procedure described in example 121 starting from 3-{5-[2-(methoxymethyl)-2′-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl chloride, prepared as in example 130, and sarcosine methyl ester hydrochloride. The title compound was obtained as a sticky solid. 1H NMR: (DMSO-d6, 300 MHz) δ 8.42 (brs, 1H), 8.28 (m, 2H), 8.17 (m, 1H), 7.61 (m, 2H), 7.34-7.22 (m, 4H), 7.12 (m, 1H), 4.32 (s, 1H), 4.22 (s, 1H), 3.80 (m, 3H), 3.32 (s, 3H), 3.1 (m, 3H). LC/MS (Method B): 486.2 (M+H)+ no (M−H)−. HPLC (Method A) Rt: 5.66 min (purity: 98.5%).

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