4-Aminobutyric acid methyl ester hydrochloride → Methyl 4-[(3-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)amino]butanoate

HRID 219970

反応式

HRID 219970 の反応式
[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[C:8]([C:10]2[O:14][N:13]=[C:12]([C:15]3[CH:16]=[C:17]([CH:21]=[CH:22][CH:23]=3)[C:18](Cl)=[O:19])[N:11]=2)[CH:7]=[CH:6][C:5]=1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[CH3:30].Cl.[NH2:32][CH2:33][CH2:34][CH2:35][C:36]([O:38][CH3:39])=[O:37]>>[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[C:8]([C:10]2[O:14][N:13]=[C:12]([C:15]3[CH:16]=[C:17]([CH:21]=[CH:22][CH:23]=3)[C:18]([NH:32][CH2:33][CH2:34][CH2:35][C:36]([O:38][CH3:39])=[O:37])=[O:19])[N:11]=2)[CH:7]=[CH:6][C:5]=1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[CH3:30]

参加物

3

反応物 2

HCID 27563834-Aminobutyric acid methyl ester hydrochlorideHCID 866456583-{5-[2-(Methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl chloride

生成物 1

HCID 59495643Methyl 4-[(3-{5-[2-(methoxymethyl)-2'-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)amino]butanoate

実験手順

The title compound was prepared following procedure described in example 121 starting from 3-{5-[2-(methoxymethyl)-2′-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl chloride and methyl 4-aminobutyrate hydrochloride (55.01 mg; 0.36 mmol) The title compound was obtained as a sticky foam (85 mg, 71%). 1H NMR: (DMSO-d6, 300 MHz) δ 8.53 (brs, 1H), 8.43 (brs, 1H), 8.32 (m, 1H), 8.17 (m, 1H), 8 (m, 1H), 7.60 (t, J=7.8 Hz, 1H), 7.34-7.22 (m, 4H), 7.12 (m, 1H), 6.65 (m, 1H), 4.22 (s, 2H), 3.69 (s, 3H), 3.56 (m, 2H), 3.32 (s, 3H), 2.48 (t, J=7 Hz, 1H), 2.07 (s, 3H), 2.01 (m, 2H). LC/MS (Method B): 500.2 (M+H)+ 498.3 (M−H)−. HPLC (Method A) Rt: 5.68 min (purity: 99.2%).

後処理

  1. customThe title compound was prepared following procedure

出典と根拠

ORDレコード
ord-a37bac729c3a4431a24295e053145dec
出典データセット
uspto-grants-2012_06
特許番号
US08202865B2

関連ノート

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