Tributylvinyltin → tert-butyl 2,3-dihydro-6-vinyl-1H-indole-1-carboxylate

反応式

Br[C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][N:8]2[C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])=[CH:4][CH:3]=1.[CH2:18]([Sn](CCCC)(CCCC)C=C)[CH2:19]CC.CC1C=CC=C(C)C=1CN1C2C(=CC=C(C(O)=O)C=2)C=C1>>[CH:18]([C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][N:8]2[C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])=[CH:4][CH:3]=1)=[CH2:19]

参加物

反応物 3

HCID 81998Tributylvinyltin

HCID 22038386tert-Butyl 6-bromoindoline-1-carboxylate

HCID 681843451-(2,6-dimethylbenzyl)-1H-indole-6-carboxylic acid

生成物 1

HCID 86707256tert-butyl 2,3-dihydro-6-vinyl-1H-indole-1-carboxylate

実験手順

The titled compound (207 mg) as a white solid was prepared from tert-butyl 6-bromo-2,3-dihydro-1H-indole-1-carboxylate obtained by the method described in the document (WO 1998/43956 A) and tributyl(vinyl)tin according to the method of the process (2) of Example 66.