1-benzyl-1H-indole-6-carboxylic acid → HCID 178437984、化合物

反応式

[Br:1][C:2]1[CH:3]=[C:4](F)[C:5]([C:8]#[N:9])=[N:6][CH:7]=1.[CH2:11]([Mg]Cl)[CH3:12].C([N:22]1C2C(=CC=C(C(O)=O)C=2)C=C1)C1C=CC=CC=1.CC1C=CC=C(C)C=1CN1C2C(=CC=C(C(O)=O)C=2)C=C1>>[Br:1][C:2]1[CH:3]=[C:4]2[NH:22][N:9]=[C:8]([CH2:11][CH3:12])[C:5]2=[N:6][CH:7]=1

参加物

反応物 4

HCID 179478751-benzyl-1H-indole-6-carboxylic acid

HCID 441966805-Bromo-3-fluoropyridine-2-carbonitrile

HCID 681843451-(2,6-dimethylbenzyl)-1H-indole-6-carboxylic acid

HCID 178461633HCID 178461633、化合物

生成物 1

HCID 178437984HCID 178437984、化合物

実験手順

The titled compound (225 mg) as a white solid was prepared from 5-bromo-3-fluoropyridin-2-carbonitrile (201 mg) obtained by the method described in the document (Journal of Organic Chemistry, 2009, Vol. 74, p. 4547) and ethylmagnesium chloride according to the methods of the processes (1) and (2) of Example 153.