Chloroacetone → 2-(3-Methoxyphenyl)-4-methyl-1,3-oxazole
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([NH2:8])=[O:7].Cl[CH2:13][C:14](=O)[CH3:15]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:6]2[O:7][CH:13]=[C:14]([CH3:15])[N:8]=2)[CH:9]=[CH:10][CH:11]=1参加物
4
実験手順
To a solution of 3-methoxybenzamide (1.5 g, 9.9 mmol) in toluene (15 mL) was added 1-chloropropan-2-one (1.37 g, 14.9 mmol), and the mixture was stirred at reflux for 16 h. The mixture was cooled and concentrated to give crude product, which was purified via silica gel chromatography eluted with ethyl acetate/petroleum ether (1:5) to give 2-(3-methoxyphenyl)-4-methyloxazole (1.21 g, 64.6% yield) as yellow syrup. LCMS MH+ 190.
後処理
- temperatureat reflux for 16 h
- temperatureThe mixture was cooled
- concentrationconcentrated
- customto give crude product, which
- customwas purified via silica gel chromatography
- washeluted with ethyl acetate/petroleum ether (1:5)
出典と根拠
- ORDレコード
- ord-c0aa7f704c2d47d6a84a1096d20c02a0
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09359359B2
反応ノート
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