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(R)-Benzyl (1-amino-1-oxo-3-phenylpropan-2-yl)carbamate → (2R)-2-amino-3-phenylpropanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (R)-Benzyl (1-amino-1-oxo-3-phenylpropan-2-yl)carbamate | HCID 68077307 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (2R)-2-amino-3-phenylpropanamide | HCID 7000171 | 98.4% |
反応手順
A mixture of (R)-benzyl 1-amino-1-oxo-3-phenylpropan-2-ylcarbamate (910 mg, 3.05 mmol) and Pd—C (10%, 200 mg) in MeOH (20 mL) was hydrogenated under balloon H2 for 16 h. It was filtered through celite. The filtrate was concentrated in vacuo to give D-phenylalanine amide as a white solid (493 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09359375B2 |
| 出典データセット | uspto-grants-2016_06 |
| ORD ID | ord-2dcf0fdbc4b14441ade349ae71152958 |
| 出典メモ | uspto-grants-2016_06 |