Thiourea → 2-(((4-Methoxybenzyl)oxy)methyl)thiirane

HRID 2201223ノート

反応式

HRID 2201223 の反応式
N[C:2](N)=[S:3].[CH3:5][O:6][C:7]1[CH:18]=[CH:17][C:10]([CH2:11][O:12][CH2:13][CH:14]2CO2)=[CH:9][CH:8]=1>CO>[CH3:5][O:6][C:7]1[CH:18]=[CH:17][C:10]([CH2:11][O:12][CH2:13][CH:14]2[CH2:2][S:3]2)=[CH:9][CH:8]=1

参加物

4

反応物 2

HCID 2723790ThioureaHCID 27740762-(((4-Methoxyphenyl)methoxy)methyl)oxirane

生成物 1

HCID 867234592-(((4-Methoxybenzyl)oxy)methyl)thiirane

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Thiourea (0.935 g, 12.28 mmol) was added to a solution of 2-(((4-methoxybenzyl)oxy)methyl) oxirane (1.084 g, 5.58 mmol) in methanol (30 mL) and the mixture stirred at room temperature for 16 hours, then evaporated under vacuum. Purification by chromatography on silica, eluting with 0-10% EtOAc/hexane, afforded the title compound.

後処理

  1. customevaporated under vacuum
  2. customPurification by chromatography on silica
  3. washeluting with 0-10% EtOAc/hexane

出典と根拠

ORDレコード
ord-e9d26d5a7c654119a2eed201ab8cc254
出典データセット
uspto-grants-2016_06
特許番号
US09359381B2

反応ノート

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