N-(2,3-Epoxypropyl)phthalimide → AGN-PC-0KLTOI

HRID 2201228ノート

反応式

HRID 2201228 の反応式
NC(N)=[S:3].O1[CH2:19][CH:6]1[CH2:7][N:8]1[C:12](=[O:13])[C:11]2=[CH:14][CH:15]=[CH:16][CH:17]=[C:10]2[C:9]1=[O:18]>CO>[S:3]1[CH2:19][CH:6]1[CH2:7][N:8]1[C:12](=[O:13])[C:11]2[C:10](=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:9]1=[O:18]

参加物

4

反応物 2

HCID 21601N-(2,3-Epoxypropyl)phthalimideHCID 2723790Thiourea

生成物 1

HCID 2828744AGN-PC-0KLTOI

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Thiourea (1.873 g, 24.61 mmol) was added to a solution of N-(2,3-epoxypropyl)phthalimide (2 g, 9.84 mmol) in methanol (25 mL). The mixture was stirred at room temperature for 16 hours, then concentrated under vacuum. The residue was diluted with water (50 ml) and extracted with ethyl acetate (50 ml). The organic extract was washed with brine (50 ml) passed through a hydrophobic frit and evaporated under vacuum. Purification by chromatography on silica, eluting with 0-50% EtOAc/hexane, afforded the title compound.

後処理

  1. concentrationconcentrated under vacuum
  2. additionThe residue was diluted with water (50 ml)
  3. extractionextracted with ethyl acetate (50 ml)
  4. extractionThe organic extract
  5. washwas washed with brine (50 ml)
  6. customevaporated under vacuum
  7. customPurification by chromatography on silica
  8. washeluting with 0-50% EtOAc/hexane

出典と根拠

ORDレコード
ord-153f62342903406099735512a6d2db4a
出典データセット
uspto-grants-2016_06
特許番号
US09359381B2

反応ノート

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