7-((4-chlorothiazol-2-yl)(hydroxy)methyl)-1,3-dimethyl-5-phenyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione → 7-((4-Chlorothiazol-2-yl)(hydroxy)methyl)-5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

反応式

[Cl:1][C:2]1[N:3]=[C:4]([CH:7]([OH:27])[C:8]2[NH:9][C:10]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[C:11]3[C:16](=[O:17])[N:15]([CH3:18])[C:14](=[O:19])[N:13]([CH3:20])[C:12]=23)[S:5][CH:6]=1.[F:28]C1C=C(C2NC(C=O)=C3C=2C(=O)N(C)C(=O)N3C)C=CC=1.C(C1C=C(C2N(CCC(N(OC)C)=O)C=C3C=2C(=O)N(C)C(=O)N3C)C=CC=1)#N>>[Cl:1][C:2]1[N:3]=[C:4]([CH:7]([OH:27])[C:8]2[NH:9][C:10]([C:21]3[CH:22]=[CH:23][CH:24]=[C:25]([F:28])[CH:26]=3)=[C:11]3[C:16](=[O:17])[N:15]([CH3:18])[C:14](=[O:19])[N:13]([CH3:20])[C:12]=23)[S:5][CH:6]=1