ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Triethylamine → 1-((tert-Butyldimethylsilyl)oxy)-4-(4-chlorothiazol-2-yl)-4-(5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-7-yl)butan-2-yl methanesulfonate

HRID 2201260
ノート
印刷プレビュー

反応式

HRID 2201260 の反応式
CS([O:5][S:6]([CH3:9])(=[O:8])=[O:7])(=O)=O.[Si:10]([O:17][CH2:18][CH:19](O)[CH2:20][CH:21]([C:28]1[NH:29][C:30]([C:41]2[CH:46]=[CH:45][CH:44]=[C:43]([F:47])[CH:42]=2)=[C:31]2[C:36](=[O:37])[N:35]([CH3:38])[C:34](=[O:39])[N:33]([CH3:40])[C:32]=12)[C:22]1[S:23][CH:24]=[C:25]([Cl:27])[N:26]=1)([C:13]([CH3:16])([CH3:15])[CH3:14])([CH3:12])[CH3:11].C(N(CC)CC)C>C(Cl)Cl>[CH3:9][S:6]([O:5][CH:19]([CH2:20][CH:21]([C:22]1[S:23][CH:24]=[C:25]([Cl:27])[N:26]=1)[C:28]1[NH:29][C:30]([C:41]2[CH:46]=[CH:45][CH:44]=[C:43]([F:47])[CH:42]=2)=[C:31]2[C:36](=[O:37])[N:35]([CH3:38])[C:34](=[O:39])[N:33]([CH3:40])[C:32]=12)[CH2:18][O:17][Si:10]([C:13]([CH3:16])([CH3:14])[CH3:15])([CH3:11])[CH3:12])(=[O:7])=[O:8]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 8471TriethylamineHCID 81560Methanesulfonic anhydrideHCID 867235007-(4-((tert-Butyldimethylsilyl)oxy)-1-(4-chlorothiazol-2-yl)-3-hydroxybutyl)-5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

生成物 1

HCID 867235011-((tert-Butyldimethylsilyl)oxy)-4-(4-chlorothiazol-2-yl)-4-(5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-7-yl)butan-2-yl methanesulfonate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Methanesulfonic anhydride (347 mg, 1.989 mmol) was added to a solution of 7-(4-((tert-butyldimethylsilyl)oxy)-1-(4-chlorothiazol-2-yl)-3-hydroxybutyl)-5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione (590 mg, 0.995 mmol) and triethylamine (0.416 mL, 2.98 mmol) in DCM (30 mL). The mixture was stirred at room temperature 20 mins. The reaction was quenched with saturated NaHCO3(aq) and extracted with DCM (3×). The combined organic extracts were passed through a hydrophobic frit and evaporated under vacuum to afford the title compound as a crude material which was used directly.

後処理

  1. customThe reaction was quenched with saturated NaHCO3(aq)
  2. extractionextracted with DCM (3×)
  3. customevaporated under vacuum

出典と根拠

ORDレコード
ord-ca0562a5139d4d1f83e451a2a2cfc038
出典データセット
uspto-grants-2016_06
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09359381B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート