Acetic Anhydride → 1-(2-Methyl-3,4-dihydroquinolin-1(2H)-yl)ethan-1-one

HRID 2201322ノート

反応式

HRID 2201322 の反応式
[CH3:1][CH:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3]1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[C:12]([N:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:10][CH2:11][CH:2]1[CH3:1])(=[O:14])[CH3:13]

参加物

3

反応物 2

HCID 7918Acetic AnhydrideHCID 962892-Methyl-1,2,3,4-tetrahydroquinoline

生成物 1

HCID 2512901-(2-Methyl-3,4-dihydroquinolin-1(2H)-yl)ethan-1-one収率 243.5%

実験手順

2-Methyl-1,2,3,4-tetrahydroquinoline (216 mg, 1.469 mmol, available from TCl), was measured into a reaction test tube and acetic anhydride (0.139 ml, 1.469 mmol) was added and left to stir overnight. LCMS analysis showed the reaction had gone to completion. The crude product was purified by MDAP to give the desired compound (677 mg)

後処理

  1. waitleft
  2. customThe crude product was purified by MDAP

出典と根拠

ORDレコード
ord-5279b24a60454a3eaa9af60440109343
出典データセット
uspto-grants-2016_06
特許番号
US09360482B2

反応ノート

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