Urea → 6-METHOXYQUINAZOLINE-2,4-DIOL

HRID 2201500ノート

反応式

HRID 2201500 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH2:13][C:14](N)=[O:15]>O>[CH3:12][O:11][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[NH:1][C:14](=[O:15])[NH:13][C:4]2=[O:6]

参加物

4

反応物 2

HCID 1176UreaHCID 2779305-Methoxyanthranilic acid

生成物 1

HCID 103302006-METHOXYQUINAZOLINE-2,4-DIOL収率 88.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
200 °C

実験手順

A mixture of 2-amino-5-methoxybenzoic acid (5.00 g, 29.9 mmol) and urea (5.40 g, 90.0 mmol) was heated to 200° C. for 1 hour. The mixture was cooled to room temperature and diluted with H2O (50 mL), the mixture was filtered off and the precipitate was washed with H2O (10 mL), dried in vacuo to give the product (5.10 g, yield 88%).

後処理

  1. temperatureThe mixture was cooled to room temperature
  2. filtrationthe mixture was filtered off
  3. washthe precipitate was washed with H2O (10 mL)
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-0334ec8119f74f7d8163db0c991f8c95
出典データセット
uspto-grants-2016_06
特許番号
US09364481B2

反応ノート

読み込み中…