Hydrochloric Acid → HCID 78324789、化合物
反応式
[CH3:1][C@@H:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][C:23]([OH:25])=[O:24])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1.Cl.[CH2:27](O)[CH3:28]>>[CH3:1][C@@H:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:16]=[CH:17][C:18]([CH2:21][CH2:22][C:23]([O:25][CH2:27][CH3:28])=[O:24])=[CH:19][CH:20]=2)=[CH:11][CH:10]=1参加物
4
反応条件
- 温度
- 60 °C
実験手順
To (R)-3-(4′-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)propanoic acid (15.8 mg, 0.047 mmol) was added 1.25M hydrogen chloride in ethanol (1.124 mL, 1.405 mmol). The reaction was stirred at 60° C. for 2 h. The mixture was concentrated and triturated with acetonitrile to give the title compound. LCMS m/z=366.6 [M+H]+; 1H NMR (400 MHz, CD3CN) δ ppm 1.22 (t, J=7.1 Hz, 3H), 1.24 (d, J=6.9 Hz, 0.5H), 1.56 (d, J=6.5 Hz, 2.5H), 1.75-1.90 (m, 1H), 1.98-2.14 (m, 2H), 2.22-2.38 (m, 1H), 2.66 (t, J=7.4 Hz, 2H), 2.97 (t, J=7.6 Hz, 2H), 3.00-3.21 (m, 3H), 3.30-3.41 (m, 2H), 3.45-3.54 (m, 1H), 3.69-3.79 (m, 1H), 4.11 (q, J=7.1 Hz, 2H), 7.31 (d, J=8.1 Hz, 2H), 7.40 (d, J=8.1 Hz, 2H), 7.58 (d, J=8.1 Hz, 2H), 7.62 (d, J=8.1 Hz, 2H).