Hydrochloric Acid → 4-[3-(4-chlorophenyl)-1H-pyrazol-5-yl]piperidine

HRID 2202151ノート

反応式

HRID 2202151 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[C:11]([CH:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]3)[NH:10][N:9]=2)=[CH:4][CH:3]=1.Cl>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[C:11]([CH:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[NH:10][N:9]=2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 7075709HCID 7075709、化合物

生成物 1

HCID 4491264-[3-(4-chlorophenyl)-1H-pyrazol-5-yl]piperidine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

INTERMEDIATE 7 was obtained by removal of the Boc group of INTERMEDIATE 1 with an acid. To a solution of INTERMEDIATE 1 (2.5 g, 6.92 mmol) in dichloromethane (10 mL) was added 4 M HCl (10 mL, 40 mmol in dioxane). The mixture was stirred at room temperature overnight. Solvent was evaporated under reduced pressure, and the residue was dried under vacuum.

後処理

  1. customSolvent was evaporated under reduced pressure
  2. customthe residue was dried under vacuum

出典と根拠

ORDレコード
ord-cda3817722e7482f9746793aec41522b
出典データセット
uspto-grants-2016_06
特許番号
US09365539B2

反応ノート

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