Triethylene glycol monomethyl ether → Cyclopropanecarboxylic Acid, 2-[2-(2-Methoxy-ethoxy)-ethoxy]-ethyl Ester

関与物質

反応条件

反応手順

Triethylene glycol monomethyl ether (1.1 eq, 5.26 mmol, 0.84 ml) and triethylamine (1.1 eq, 5.26 mmol, 0.73 ml) were taken in a 10 ml round bottom flask and dichloromethane (3 ml) was added. This mixture was cooled to 0° C. and then cyclopropanecarbonyl chloride (4.78 mmol, 0.5 g, 0.43 ml) was added in a dropwise fashion maintaining the temperature at 0° C. with constant stirring.

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