(E)-tert-butyl 4-hydroxy-4-(4,4,4-trifluorobut-1-enyl)piperidine-1-carboxylate → (E)-4-(4,4,4-trifluorobut-1-enyl)piperidin-4-ol

HRID 2202404ノート

反応式

HRID 2202404 の反応式
[OH:1][C:2]1(/[CH:15]=[CH:16]/[CH2:17][C:18]([F:21])([F:20])[F:19])[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1>Cl.O1CCOCC1>[F:21][C:18]([F:19])([F:20])[CH2:17]/[CH:16]=[CH:15]/[C:2]1([OH:1])[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1

参加物

3

反応物 1

HCID 90447581(E)-tert-butyl 4-hydroxy-4-(4,4,4-trifluorobut-1-enyl)piperidine-1-carboxylate

生成物 1

HCID 90447571(E)-4-(4,4,4-trifluorobut-1-enyl)piperidin-4-ol

試薬・触媒・溶媒 1

HCID 204431481,4-Dioxane hydrochloride溶媒

実験手順

A solution of (E)-tert-butyl 4-hydroxy-4-(4,4,4-trifluorobut-1-enyl)piperidine-1-carboxylate (200 mg, 0.65 mmol) in 3M HCl/1,4-dioxane (5 mL) was stirred at room temperature for 2 hours. The solution was evaporated to dryness under reduced pressure to give the product which was used in the next step without further purification. LC-MS: m/z 210.2 (M+H)+.

後処理

  1. customThe solution was evaporated to dryness under reduced pressure
  2. customto give the product which
  3. customwas used in the next step without further purification

出典と根拠

ORDレコード
ord-310f82fc156743a8be66a2e03a261a1b
出典データセット
uspto-grants-2016_06
特許番号
US09365545B2

反応ノート

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