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[2-(2-Amino-3-methoxy-phenylcarbamoyl)-ethyl]-methyl-carbamic acid tert.-butyl ester → HCID 178488952、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | [2-(2-Amino-3-methoxy-phenylcarbamoyl)-ethyl]-methyl-carbamic acid tert.-butyl ester | HCID 68411798 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | HCID 178488952 | HCID 178488952 | 75.6% |
反応手順
A solution of 2.1 g of crude [2-(2-amino-3-methoxy-phenylcarbamoyl)-ethyl]-methyl-carbamic acid tert.-butyl ester in 10 mL acetic acid was heated at 65° C. for 2 h. The reaction mixture was concentrated and purified by CC with EtOAc to yield 1.5 g of [2-(7-methoxy-1H-benzoimidazol-2-yl)-ethyl]-methyl-carbamic acid tert.-butyl ester as orange foam.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08202885B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-2221cab70cb74afabc02b086ed5cf267 |
| 出典メモ | uspto-grants-2012_06 |