化工社化工社 化学情報印刷レポート · 研究参考用
Trifluoroacetic acid → HCID 178483309、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | HCID 178488952 | HCID 178488952 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 178483309 | HCID 178483309 | 37.7% |
反応手順
A solution of 1.5 g of [2-(7-methoxy-1H-benzoimidazol-2-yl)-ethyl]-methyl-carbamic acid tert.-butyl ester in 10 mL DCM was treated with 0.39 mL of TFA and stirred overnight at rt. The reaction mixture was concentrated in vacuo, redissolved in DCM and treated with diluted NaOH. After separation of the 2 phases the water phase was lyophilized to yield 380 mg of [2-(7-methoxy-1H-benzoimidazol-2-yl)-ethyl]-methyl-amine as beige solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08202885B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-9d1d1ccde96d430e95a9e09857093f57 |
| 出典メモ | uspto-grants-2012_06 |