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Triethylamine → 2-Difluoroacetylimino-3(3-trifluoromethylphenyl)-5-methylthiazoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Difluoroacetic acid | HCID 9788 | — |
| 反応物 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 反応物 | 2-Imino-3-(3-trifluoromethyl-phenyl)-5-methylthiazoline hydrochloride | HCID 21480071 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 2-Difluoroacetylimino-3(3-trifluoromethylphenyl)-5-methylthiazoline | HCID 11088983 | 62.6% |
反応手順
A mixture of 2-imino-3-(3-trifluoromethylphenyl)-5-methylthiazoline hydrochloride (0.42 g), triethylamine (2.2 g), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (0.8 g) and difluoroacetic acid (0.75 g) in chloroform (10 ml) was refluxed for 8 hours. The residue was washed with aqueous hydrochloric acid and aqueous potassium carbonate and dried over magnesium sulfate. The solvent was removed under reduced pressure, and the residue was subjected to column chromatography to give 2-difluoroacetylimino-3-(3-trifluoromethylphenyl)-5-methylthiazoline (Compound No. 63) (0.3 g). m.p., 117.9° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05426188 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-840ef424ea6848aab829e8871146298a |
| 出典メモ | uspto-grants-1995_06 |