Diisobutylaluminumhydride → 1-(Trifluoromethyl)cyclopropanecarboxaldehyde

HRID 2202672ノート

反応式

HRID 2202672 の反応式
CON(C)[C:4]([C:6]1([C:9]([F:12])([F:11])[F:10])[CH2:8][CH2:7]1)=[O:5].[H-].C([Al+]CC(C)C)C(C)C>C(Cl)Cl>[F:10][C:9]([F:12])([F:11])[C:6]1([CH:4]=[O:5])[CH2:8][CH2:7]1

参加物

4

反応物 2

HCID 21225700DiisobutylaluminumhydrideHCID 57785368N-methoxy-N-methyl-1-(trifluoromethyl)cyclopropane-1-carboxamide

生成物 1

HCID 574451861-(Trifluoromethyl)cyclopropanecarboxaldehyde

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

To a stirred solution of compound A103-1 (164 mg, 0.832 mmol) in DCM (2 mL) was added diisobutylaluminum hydride (1 M in hexane, 1.0 mL, 1.0 mmol) at −78° C. under nitrogen atmosphere. After 0.5 h, the mixture was allowed to warm to 0° C. and stirred for 0.5 h. The reaction mixture was quenched with sat. KHSO4 aq. (10 mL) and extracted with DCM (2×4 mL). The combined organic layers were directly used in the next step without further purification.

後処理

  1. customThe reaction mixture was quenched with sat. KHSO4 aq. (10 mL)
  2. extractionextracted with DCM (2×4 mL)
  3. customThe combined organic layers were directly used in the next step without further purification

出典と根拠

ORDレコード
ord-4ab3b65041f245cb860bc5961bff4bed
出典データセット
uspto-grants-2016_06
特許番号
US09365522B2

反応ノート

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