Acetic Anhydride → N-(2-Chloro-5-methoxyphenyl)acetamide
反応式
[Cl:1][C:2]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:3]=1[NH2:4].[C:11](OC(=O)C)(=[O:13])[CH3:12]>CC(O)=O>[Cl:1][C:2]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:3]=1[NH:4][C:11](=[O:13])[CH3:12]参加物
4
実験手順
To a solution of 10.59 g of 2-chloro-5-methoxyaniline in 50 mL of AcOH were added dropwise at 0° C. 6.8 mL of acetic anhydride. The reaction mixture was allowed to warm up to rt, stirred for 6 h and concentrated in vacuo. The crude product was purified by CC using EtOAc/heptane 1/3 to yield 13.0 g of N-(2-chloro-5-methoxy-phenyl)-acetamide as white solid.
後処理
- concentrationconcentrated in vacuo
- customThe crude product was purified by CC
出典と根拠
- ORDレコード
- ord-6bdd3efc020643ea87201df1f991d82f
- 出典データセット
- uspto-grants-2012_06
- 特許番号
- US08202885B2
反応ノート
読み込み中…