Hydrochloric Acid → 4-(Benzyloxy)-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one hydrochloride

HRID 2202904ノート

反応式

HRID 2202904 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][N:12]([C:15]2[CH:16]=[CH:17][C:18]3[N:19]([C:21]([CH3:27])=[C:22]([CH:24]4[CH2:26][CH2:25]4)[N:23]=3)[CH:20]=2)[C:11](=[O:28])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:29]>CCOC(C)=O>[ClH:29].[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][N:12]([C:15]2[CH:16]=[CH:17][C:18]3[N:19]([C:21]([CH3:27])=[C:22]([CH:24]4[CH2:26][CH2:25]4)[N:23]=3)[CH:20]=2)[C:11](=[O:28])[CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 89690318HCID 89690318、化合物

生成物 1

HCID 896905354-(Benzyloxy)-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one hydrochloride

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To a suspension of 4-(benzyloxy)-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one (50 mg) in EtOAc (3 ml) was added 4 M HCl (EtOAc solution) (0.067 ml), and the mixture was stirred at room temperature for 3 h. The resulting solid was collected, washed with EtOAc, and dried in vacuo to give the title compound (44.0 mg) as a white solid.

後処理

  1. customThe resulting solid was collected
  2. washwashed with EtOAc
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-4e00d07da37e4f84b5130cc98bdbfe32
出典データセット
uspto-grants-2016_06
特許番号
US09365540B2

反応ノート

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