2-Methyl-2H-indazole-7-carbonitrile → HCID 44119221、化合物

HRID 2203196ノート

反応式

HRID 2203196 の反応式
[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([C:5]([C:11]#[N:12])=[CH:6][CH:7]=[CH:8]2)=[N:3]1>CO.N.[Ni]>[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([C:5]([CH2:11][NH2:12])=[CH:6][CH:7]=[CH:8]2)=[N:3]1

参加物

5

反応物 1

HCID 441192602-Methyl-2H-indazole-7-carbonitrile

生成物 1

HCID 44119221HCID 44119221、化合物

試薬・触媒・溶媒 3

HCID 935Nickel触媒HCID 222Ammonia溶媒HCID 887Methanol溶媒

実験手順

To a solution of 2-methyl-2H-indazole-7-carbonitrile (1 equiv.) in methanol and aq. ammonia solution (9:1), catalytic amount of Raney Nickel was added. Reaction mass was stirred at room temperature under hydrogen pressure (balloon pressure) for 2-5 h. On completion of reaction, it was filtered through celite bed and filtrate was concentrated under reduce pressure to afford the title compound (quant. yield).

後処理

  1. customReaction mass
  2. customOn completion of reaction, it
  3. filtrationwas filtered through celite bed and filtrate
  4. concentrationwas concentrated

出典と根拠

ORDレコード
ord-00b707e22aea479580541497fb8201d3
出典データセット
uspto-grants-2016_06
特許番号
US09365570B2

反応ノート

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