Triethylamine → 5-Bromo-2-(3-hydroxy-3-methylbutyl)isoindolin-1-one

HRID 2203218ノート

反応式

HRID 2203218 の反応式
[Br:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=O)=[C:4]([CH2:12]Br)[CH:3]=1.[NH2:14][CH2:15][CH2:16][C:17]([CH3:20])([OH:19])[CH3:18].CCN(CC)CC>CO>[Br:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:10][CH:11]=1)[C:6](=[O:8])[N:14]([CH2:15][CH2:16][C:17]([OH:19])([CH3:20])[CH3:18])[CH2:12]2

参加物

5

反応物 3

HCID 8471TriethylamineHCID 156491734-Amino-2-methylbutan-2-olHCID 22031079Methyl 4-bromo-2-(bromomethyl)benzoate

生成物 1

HCID 231583295-Bromo-2-(3-hydroxy-3-methylbutyl)isoindolin-1-one

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
85 °C

実験手順

To methyl 4-bromo-2-(bromomethyl)benzoate (0.220 g, 0.714 mmol) suspended in MeOH (6.0 mL) were added 4-amino-2-methylbutan-2-ol (0.077 g, 0.750 mmol) and Et3N (0.156 mL, 1.107 mmol). The mixture was heated to reflux (85° C.) for 24 hours, then cooled to RT, and concentrated in vacuo to give the title compound, which was used without further purification.

後処理

  1. temperatureThe mixture was heated
  2. temperaturecooled to RT
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-b4703082cc7f4b1f9aa93a2627270c78
出典データセット
uspto-grants-2016_06
特許番号
US09365566B2

反応ノート

読み込み中…