3-(Methylthio)phenyl isocyanate → HCID 178503187、化合物

HRID 2203276ノート

反応式

HRID 2203276 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:22][N:12]3[C:13](=[O:21])[NH:14][C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][C:20]=4[C:11]3=[N:10][CH2:9]2)=[CH:4][CH:3]=1.[CH3:23][S:24][C:25]1[CH:26]=[C:27]([N:31]=[C:32]=[O:33])[CH:28]=[CH:29][CH:30]=1>>[CH3:23][S:24][C:25]1[CH:26]=[C:27]([NH:31][C:32]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([CH:8]3[CH2:22][N:12]4[C:13](=[O:21])[NH:14][C:15]5[CH:16]=[CH:17][CH:18]=[CH:19][C:20]=5[C:11]4=[N:10][CH2:9]3)=[CH:4][CH:3]=2)=[O:33])[CH:28]=[CH:29][CH:30]=1

参加物

3

反応物 2

HCID 1414183-(Methylthio)phenyl isocyanateHCID 178507413HCID 178507413、化合物

生成物 1

HCID 178503187HCID 178503187、化合物収率 47%

実験手順

In a manner similar to the procedure described in Example 7, 3-(4-aminophenyl)-2,3,4,7-tetrahydro-6H-pyrimido[1,2-c]quinazolin-6-one (20.2 mg, 0.069 mmol) and 3-(methylthio)phenyl isocyanate (0.0105 mL, 0.076 mmol) were reacted to give the title compound as an off-white solid (14.8 mg, 47%). 1H NMR (DMSO-d6) δ: 10.68 (s, 1H), 8.69 (s, 1H), 8.66 (s, 1H), 7.98 (d, J=7.9 Hz, 1H), 7.41-7.47 (m, 4H), 7.19-7.26 (m, 3H), 7.13-7.15 (m, 1H), 7.06 (t, J=7.5 Hz, 1H), 7.01 (d, J=7.9 Hz, 1H), 6.84-6.87 (m, 1H), 4.22 (dt, J=12.7, 3.0 Hz, 1H), 3.70-3.75 (m, 1H), 3.51-3.59 (m, 2H), 2.93-2.99 (m, 1H), 2.45 (s, 3H).

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-ac45202fa9524774ae69dc154879cb76
出典データセット
uspto-grants-2016_06
特許番号
US09365575B2

反応ノート

読み込み中…