関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pyrazinamide | HCID 1046 | — |
| 反応物 | Isoniazid | HCID 3767 | — |
| 反応物 | Ethambutol | HCID 14052 | — |
| 反応物 | Rifampicin | HCID 135398735 | — |
| 反応物 | HCID 178484872 | HCID 178484872 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Isoniazid | HCID 3767 | — |
| 生成物 | Ethambutol | HCID 14052 | — |
| 生成物 | Sq-109 | HCID 5274428 | — |
| 生成物 | HCID 178484872 | HCID 178484872 | — |
反応手順
Antimicrobial drugs isoniazid, rifampicin, streptomycin, and ethambutol were purchased from Sigma-Aldrich. St. Louis, Mo. Stock solutions of isoniazid, streptomycin, and ethambutol were prepared in distilled and deionized water at 10 mg/mL, sterilized by filtration, and stored frozen at −80° C. Stock solutions of rifampicin, at 1 or 10 mg/mL, were prepared in methanol and stored at −80° C. Pyrazinamide was purchased as the drug reconstituting kit from Becton Dickinson, Cockeysville, Md., and a stock solution was prepared following instructions by the manufacturer. Stock solutions of SQ109 were prepared in methanol at 1 mg/mL and stored at 80° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08202910B2 |
|---|
| 出典データセット | uspto-grants-2012_06 |
|---|
| ORD ID | ord-7db65914d01d4f049bfc3bd1369acb02 |
|---|
| 出典メモ | uspto-grants-2012_06 |
|---|
