Ammonia → Imidazo[1,5-a]pyrimidine-6-carboxamide,8-(3,3,4,4,4-pentafluorobutyl)-
反応式
[F:1][C:2]([F:23])([C:19]([F:22])([F:21])[F:20])[CH2:3][CH2:4][C:5]1[N:6]=[C:7]([C:14]([O:16]CC)=O)[N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12.[NH3:24]>>[F:1][C:2]([F:23])([C:19]([F:21])([F:22])[F:20])[CH2:3][CH2:4][C:5]1[N:6]=[C:7]([C:14]([NH2:24])=[O:16])[N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12参加物
3
実験手順
A solution of the intermediate from Step D (0.3684 g, 1.092 mmol) and ammonia (11.70 mL, 82 mmol, 7 N in MeOH) was heated at 50° C. under N2 in a screw cap vial for 24 h. The reaction mixture was concentrated in vacuo to remove the excess amine to afford the desired product, as a yellow solid. m/z=309.1 (M+H).
後処理
- customcap vial for 24 h
- concentrationThe reaction mixture was concentrated in vacuo
- customto remove the excess amine
出典と根拠
- ORDレコード
- ord-5188009fae0646fc811dd728ebbb36f2
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09365574B2
反応ノート
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