Dimethylamine → (3-Methanesulfonylpropyl)dimethylamine
反応式
Br[CH2:2][CH2:3][CH2:4][S:5]([CH3:8])(=[O:7])=[O:6].[CH3:9][NH:10][CH3:11]>CCOCC>[CH3:8][S:5]([CH2:4][CH2:3][CH2:2][N:10]([CH3:11])[CH3:9])(=[O:7])=[O:6]参加物
4
実験手順
1-Bromo-3-methanesulfonylpropane (500 mg, 2.5 mmol) was suspended in a dimethylamine solution (2 M in THF; 10 mL, 20 mmol) and stirred at RT, resulting in a crystalline solid. The reaction was left to stand overnight and the reaction mixture was then diluted with Et2O (10 mL) and filtered. The filtrate was concentrated in vacuo resulting in an orange oily solid which was redissolved in Et2O (10 mL), filtered and concentrated in vacuo to give the title compound as an orange oil (420 mg).
後処理
- customresulting in a crystalline solid
- waitThe reaction was left
- filtrationfiltered
- concentrationThe filtrate was concentrated in vacuo
- customresulting in an orange oily solid which
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-fb7ddbf1c4e14576a3d951e3dfa149c1
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09365577B2
反応ノート
読み込み中…