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Tributylstannane → 2-Ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tributylstannane | HCID 5948 | — |
| 反応物 | Benzoyl Peroxide | HCID 7187 | — |
| 反応物 | 2-Ethoxycarbonylimino-3-(3-trifluoromethylpheny)-5-bromothiazoline | HCID 54096993 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazoline | HCID 54352089 | 75.8% |
反応手順
A solution of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-bromothiazoline (4.7 g), tributyltin hydride (6.9 g) and a catalytic amount of benzoyl peroxide in tetrahydrofuran (100 ml) was refluxed for 10 hours. The solvent was removed by distillation, and the residue was washed with hexane. Recrystallization from a mixture of hexane and ethanol gave 2.85 g of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl) thiazoline (Compound (xii)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05426188 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-c6888d67ee3542789f12cd043e1c654d |
| 出典メモ | uspto-grants-1995_06 |