Bromine → 1-Bromo-1-(methylsulfonyl)-2-propanone

HRID 220370

反応式

HRID 220370 の反応式
[CH3:1][S:2]([CH2:5][C:6](=[O:8])[CH3:7])(=[O:4])=[O:3].[Br:9]Br>CC(O)=O.ClCCl>[Br:9][CH:5]([S:2]([CH3:1])(=[O:4])=[O:3])[C:6](=[O:8])[CH3:7]

参加物

5

反応物 2

HCID 24408BromineHCID 786951-(Methylsulphonyl)acetone

生成物 1

HCID 581805331-Bromo-1-(methylsulfonyl)-2-propanone収率 42.1%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 6344Dichloromethane溶媒

実験手順

To a solution of methanesulphonylacetone (0.5 g, 3.67 mmol) in AcOH (7.34 mL) and dichloromethane (11.02 mL) in a round bottom flask was added bromine (0.189 mL, 3.67 mmol) dropwise. The reaction mixture was stirred at rt 90 min. Solvent was removed in vacuo. The residue was taken up in ether and washed with saturated aqueous sodium bicarbonate (2×). The organics were concentrated in vacuo. 1-Bromo-1-(methylsulfonyl)propan-2-one (0.332 g, 42% yield) was isolated as an oil.

後処理

  1. customSolvent was removed in vacuo
  2. washwashed with saturated aqueous sodium bicarbonate (2×)
  3. concentrationThe organics were concentrated in vacuo

出典と根拠

ORDレコード
ord-d904e2e21c024f3489eba3c9a23001ad
出典データセット
uspto-grants-2012_06
特許番号
US08202881B2

関連ノート

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