Sodium Acetate → HCID 178496248、化合物

HRID 2204289

反応式

HRID 2204289 の反応式
[C:1]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][N+:9]1[C:17]2[C:12](=[CH:13][C:14]([S:18]([OH:21])(=[O:20])=[O:19])=[CH:15][CH:16]=2)[C:11]([CH3:29])([CH2:22][CH2:23][CH2:24][S:25]([OH:28])(=[O:27])=[O:26])[C:10]=1/[CH:30]=[CH:31]/NC1C=CC=CC=1)([OH:3])=[O:2].[CH3:39][O:40][CH2:41][CH2:42][O:43][CH2:44][CH2:45][O:46][CH2:47][CH2:48][N+:49]1[C:57]2[C:52](=[CH:53][C:54]([S:58]([OH:61])(=[O:60])=[O:59])=[CH:55][CH:56]=2)[C:51]([CH3:69])([CH2:62][CH2:63][CH2:64][S:65]([OH:68])(=[O:67])=[O:66])[C:50]=1[CH3:70].C([O-])(=O)C.[Na+:75].COCCOCC[N+]1C2C(=CC(S(O)(=O)=O)=CC=2)C(C)(CCCS(O)(=O)=O)C=1C>C(O)(=O)C.C(OC(=O)C)(=O)C.C(OCC)C>[Na+:75].[Na+:75].[Na+:75].[C:1]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][N:9]1[C:17]2[C:12](=[CH:13][C:14]([S:18]([OH:21])(=[O:20])=[O:19])=[CH:15][CH:16]=2)[C:11]([CH3:29])([CH2:22][CH2:23][CH2:24][S:25]([OH:28])(=[O:26])=[O:27])/[C:10]/1=[CH:30]\[CH:31]=[CH:70]\[C:50]1[C:51]([CH3:69])([CH2:62][CH2:63][CH2:64][S:65]([OH:68])(=[O:67])=[O:66])[C:52]2[C:57](=[CH:56][CH:55]=[C:54]([S:58]([OH:61])(=[O:59])=[O:60])[CH:53]=2)[N+:49]=1[CH2:48][CH2:47][O:46][CH2:45][CH2:44][O:43][CH2:42][CH2:41][O:40][CH3:39])([OH:3])=[O:2]

参加物

7

反応物 4

HCID 517045Sodium AcetateHCID 885363471-(5-carboxypentyl)-3-methyl-2-((E)-2-phenylamino-vinyl)-5-sulfo-3-(3-sulfopropyl)-3H-indoliumHCID 885363611-[2-(2-methoxy-ethoxy)-ethyl]-2,3-dimethyl-5-sulfo-3-(3-sulfopropyl)-3H-indolium2 回HCID 885363881-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethyl}-2,3-dimethyl-5-sulfo-3-(3-sulfo-propyl)-3H-indolium

生成物 1

HCID 178496248HCID 178496248、化合物

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 21895370AcOH AcOAc溶媒

実験手順

One mmol 1-(5-carboxypentyl)-3-methyl-2-((E)-2-phenylamino-vinyl)-5-sulfo-3-(3-sulfopropyl)-3H-indolium and 1 mmol 1-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethyl}-2,3-dimethyl-5-sulfo-3-(3-sulfo-propyl)-3H-indolium were dissolved in 20 ml acetic acid/acetic anhydride (1/1) followed by the addition of 200 mg sodium acetate. The solution was stirred under reflux for 15 min. After cooling to room temperature, 20 ml diethylether was added. The resulting precipitate (mixture of the diastereomers 550-1 compound 2 and 550-2 compound 2) was extracted by suction, washed with ether and dried.

後処理

  1. temperatureunder reflux for 15 min
  2. extractionwas extracted by suction
  3. washwashed with ether
  4. customdried

出典と根拠

ORDレコード
ord-a4a989fdea8a45c294497d0c06443fce
出典データセット
uspto-grants-2016_06
特許番号
US09365598B2

関連ノート

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