Hydrochloric Acid → (S)-tert-butyl 2-(2-aminobutoxy)acetate

HRID 2204987ノート

反応式

HRID 2204987 の反応式
C(OC([NH:8][C@@H:9]([CH2:20][CH3:21])[CH2:10][O:11][CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])=O)(C)(C)C.Cl.O1CCOCC1>C(Cl)Cl>[NH2:8][C@@H:9]([CH2:20][CH3:21])[CH2:10][O:11][CH2:12][C:13]([O:15][C:16]([CH3:18])([CH3:17])[CH3:19])=[O:14]

参加物

5

反応物 3

HCID 313Hydrochloric Acid2 回HCID 312751,4-Dioxane2 回HCID 86678281(S)-tert-butyl 2-(2-(tert-butoxycarbonylamino)butoxy)acetate

生成物 1

HCID 87385354(S)-tert-butyl 2-(2-aminobutoxy)acetate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of (S)-tert-butyl 2-(2-(tert-butoxycarbonylamino)butoxy)acetate (1 eq, from the previous step) in DCM (0.4 M) at room temperature was added a solution of 4 M HCl in dioxane (10 eq). The reaction was stirred for 2 hours, at which time more 4 M HCl in dioxane (3 eq) was added and stirred for 1 hour. The reaction mixture was concentrated en vaccuo to give the product as an oil. The material was carried onto the next step without further purification.

後処理

  1. additionwas added
  2. concentrationThe reaction mixture was concentrated en vaccuo

出典と根拠

ORDレコード
ord-29982f93124d4af4997245f0abfa0b43
出典データセット
uspto-grants-2016_06
特許番号
US09365506B2

反応ノート

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