Hydrochloric Acid → Benzyl 6-aminohexanoate hydrochloride
反応式
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15])=O)(C)(C)C.[ClH:24].O1CCOCC1>C(Cl)Cl>[ClH:24].[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15]参加物
5
実験手順
To a solution of benzyl 6-(tert-butoxycarbonylamino)hexanoate (1 eq) in DCM (0.17 M) was added 4M HCl in dioxane (30 eq). The resulting mixture was stirred at room temperature for 1 hour. The mixture was concentrated en vaccuo. The crude material was dissolved in DCM and precipitated in diethyl ether to give the product as a white solid.
後処理
- concentrationThe mixture was concentrated en vaccuo
- dissolutionThe crude material was dissolved in DCM
- customprecipitated in diethyl ether
出典と根拠
- ORDレコード
- ord-677ce6968d8f45078bd719c52386bec1
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09365506B2
反応ノート
読み込み中…