Potassium Carbonate → Ethyl 2-(2-methylimidazo[2,1-b]thiazol-6-yl)acetate
反応式
Br.[CH3:2][C:3]1[S:7][C:6]2=[N:8][C:9]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:10][N:5]2[CH:4]=1.C(=O)([O-])[O-].[K+].[K+]>O>[CH3:2][C:3]1[S:7][C:6]2=[N:8][C:9]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:10][N:5]2[CH:4]=1参加物
4
実験手順
Ethyl (2-methylimidazo[2,1-b][1,3]thiazol-6-yl)acetate hydrobromide (226 g, 0.74 mol) was dissolved in water (350 mL) and the solution was adjusted to pH 7 by addition of potassium carbonate (51.0 g, 0.37 mol). The aqueous solution was extracted with methylene chloride (300 mL) and the organic phase was washed with brine (150 mL), dried over anhydrous magnesium sulfate, filtered and concentrated to give ethyl (2-methylimidazo[2,1-b][1,3]thiazol-6-yl)acetate as a brown oil (151.3 g).
後処理
- extractionThe aqueous solution was extracted with methylene chloride (300 mL)
- washthe organic phase was washed with brine (150 mL)
- dry with materialdried over anhydrous magnesium sulfate
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-724238e37e43407da29e572879ecbebc
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09370516B2
反応ノート
読み込み中…