Dioxane Methanol → HCID 118294342、化合物
反応式
C([O:4][C@@H:5]1[C@H:9]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C@:8]([CH2:21][O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([CH:18]([F:20])[F:19])[O:7][C@H:6]1[N:30]1[CH:35]=[CH:34][C:33](=[O:36])[NH:32][C:31]1=[O:37])(=O)C.CO.O1CCOCC1>N>[CH2:11]([O:10][C@@H:9]1[C@:8]([CH2:21][O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([CH:18]([F:19])[F:20])[O:7][C@@H:6]([N:30]2[CH:35]=[CH:34][C:33](=[O:36])[NH:32][C:31]2=[O:37])[C@@H:5]1[OH:4])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1参加物
4
実験手順
A solution of compound 6 (0.52 g, 1 mmol) in NH3.MeOH/dioxane (6 mL/6 mL) was stirred at 20° C. After 18 h the reaction mixture was evaporated to dryness under reduced pressure. Purification by silica gel chromatography [petroleum ether:ethyl acetate (4:1 to 1.5:1)] provided 32 (0.314 g, 61%) as a white solid.