化工社化工社 化学情報印刷レポート · 研究参考用
Indole → (E)-12-methyl-7,8,9,10,13a, 14-hexahydroazecino[1,2-a]indol-6(13H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Indole | HCID 798 | — |
| 反応物 | Ethylaluminum dichloride | HCID 11237 | — |
| 反応物 | 3H-Indole | HCID 3083560 | — |
| 反応物 | Cyclohexanone, 2-(1-methylethenyl)- | HCID 11018939 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 生成物 | (E)-12-methyl-7,8,9,10,13a, 14-hexahydroazecino[1,2-a]indol-6(13H)-one | HCID 131735804 | 77% |
反応手順
Following the general procedure as described in Example 17, 2-(prop-1-en-2-yl)cyclohexanone (0.88 g, 6.38 mmol), 1H-indole (0.90 g, 7.65 mmol) which was in situ isomerized to 3H-indole, and EtAlCl2 (0.81 g, 6.38 mmol) in 1,2-dichloroethane (65 ml) were reacted to give the title product as a white solid (1.25 g, 77% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09371262B2 |
| 出典データセット | uspto-grants-2016_06 |
| ORD ID | ord-9db42c8f2994453d8750ec9104891608 |
| 出典メモ | uspto-grants-2016_06 |