Tin tetrachloride → (E)-1-methoxy-10,12-dimethylazacyclododec-9-en-2-one

HRID 2205260ノート

反応式

HRID 2205260 の反応式
[CH2:1]=[C:2]([CH:4]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][C:5]1=[O:12])[CH3:3].[CH3:13][O:14][N:15]=[CH:16][CH3:17].Cl[Sn](Cl)(Cl)Cl>ClCCCl>[CH3:13][O:14][N:15]1[CH:16]([CH3:17])[CH2:3][C:2]([CH3:1])=[CH:4][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][C:5]1=[O:12]

参加物

5

反応物 3

HCID 24287Tin tetrachlorideHCID 535486Acetaldehyde, O-methyloximeHCID 895256422-(Prop-1-en-2-yl)cyclooctanone

生成物 1

HCID 89525670(E)-1-methoxy-10,12-dimethylazacyclododec-9-en-2-one収率 89%

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

Following the general procedure as described in Example 23, 2-(prop-1-en-2-yl)cyclooctanone (1.50 g, 9.02 mmol), acetaldehyde O-methyl oxime (0.99 g, 13.53 mmol), and SnCl4 (2.35 g, 9.02 mmol) in 1,2-dichloroethane (90 ml) were reacted to give the title product as a colorless liquid (1.91 g, 89% yield). E isomer>95%.

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-d311682aad17414d83a0e453534e969f
出典データセット
uspto-grants-2016_06
特許番号
US09371262B2

反応ノート

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