(R)-Quinuclidin-3-yl ((S)-(3-(2-((4-(hydroxymethyl)phenyl)amino)-2-oxoethoxy)phenyl)(phenyl)methyl)carbamate → (R)-Quinuclidin-3-yl ((S)-(3-(2-((4-formylphenyl)amino)-2-oxoethoxy)phenyl)-(phenyl)methyl)carbamate
反応式
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:38])[CH2:11][O:12][C:13]2[CH:14]=[C:15]([C@@H:19]([NH:26][C:27](=[O:37])[O:28][C@@H:29]3[CH:34]4[CH2:35][CH2:36][N:31]([CH2:32][CH2:33]4)[CH2:30]3)[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH:16]=[CH:17][CH:18]=2)=[CH:5][CH:4]=1>O1CCOCC1.[O-2].[Mn+4].[O-2]>[CH:2]([C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10](=[O:38])[CH2:11][O:12][C:13]2[CH:14]=[C:15]([C@@H:19]([NH:26][C:27](=[O:37])[O:28][C@@H:29]3[CH:34]4[CH2:33][CH2:32][N:31]([CH2:36][CH2:35]4)[CH2:30]3)[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH:16]=[CH:17][CH:18]=2)=[CH:7][CH:8]=1)=[O:1]参加物
4
反応物 1
生成物 1
試薬・触媒・溶媒 2
実験手順
To a stirred solution of (R)-quinuclidin-3-yl ((S)-(3-(2-((4-(hydroxymethyl)-phenyl)amino)-2-oxoethoxy)phenyl)(phenyl)methyl)carbamate (0.68 g, 1.31 mmol) in 1,4-dioxane (10 mL) was added manganese (IV) oxide (0.57 g, 6.58 mmol). The reaction mixture was stirred at room temperature for 60 hours. The suspension was filtered and the filter cake was washed with ethyl acetate. The filtrate was evaporated at reduced pressure to afford the crude title compound. This material was used without further purification.