Potassium Carbonate → 1-(difluoromethyl)-4-ethynyl-1H-pyrazole
反応式
[F:1][CH:2]([F:14])[N:3]1[CH:7]=[C:6]([C:8]#[C:9][Si](C)(C)C)[CH:5]=[N:4]1.C(=O)([O-])[O-].[K+].[K+]>CO>[F:1][CH:2]([F:14])[N:3]1[CH:7]=[C:6]([C:8]#[CH:9])[CH:5]=[N:4]1参加物
4
実験手順
1-(Difluoromethyl)-4-((trimethylsilyl)ethynyl)-1H-pyrazole (Preparation 151, 413 mg, 1.9 mmole) was stirred with methanol (4 mL). Potassium carbonate (17 mg) was added and stirred at room temperature for 50 minutes. The solvent was evaporated and the residue was filtered in dichloromethane through a short pad of silica to afford the title compound (187 mg 1.31 mmole 72%). 1H-NMR (CDCl3, 500 MHz): δ 3.08 (s, 1H), 7.17 (t, J=60.5 Hz, 1H), 7.75 (s, 1H), 7.97 (s, 1H).
後処理
- customThe solvent was evaporated
- filtrationthe residue was filtered in dichloromethane through a short pad of silica
出典と根拠
- ORDレコード
- ord-a7eac286688e4b9d9596b38ba463631b
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09371319B2
反応ノート
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