Hydrogen chloride-ethyl acetate → Oxan-4-ylhydrazine dihydrochloride

HRID 2205996

反応式

HRID 2205996 の反応式
[O:1]1[CH2:6][CH2:5][CH:4]([NH:7][NH:8]C(OC(C)(C)C)=O)[CH2:3][CH2:2]1.C(OCC)(=O)C.[ClH:22]>>[ClH:22].[ClH:22].[O:1]1[CH2:6][CH2:5][CH:4]([NH:7][NH2:8])[CH2:3][CH2:2]1

参加物

3

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 45092245N'-(oxan-4-yl)(tert-butoxy)carbohydrazide

生成物 1

HCID 50988431Oxan-4-ylhydrazine dihydrochloride

実験手順

tert-Butyl 2-(tetrahydro-2H-pyran-4-yl)hydrazinecarboxylate (1.82 g) was dissolved in 4N hydrogen chloride-ethyl acetate solution (85 mL) under ice-cooling, and the solution was stirred overnight at room temperature. The reaction mixture was concentrated under reduced pressure to give the title compound (1.52 g).

後処理

  1. temperaturecooling
  2. concentrationThe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-e0bf9401af274c7fb0f43c5a4cd2ab76
出典データセット
uspto-grants-2016_06
特許番号
US09371320B2

関連ノート

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