反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([NH2:9])[CH:3]=1.[Cl:10][C:11]1[CH:12]=C[CH:14]=[C:15]2NC(=O)OC(=O)[C:16]=12.[C:23]([OH:26])(=O)[CH3:24]>>[Cl:10][C:11]1[CH:16]=[CH:15][C:14]2[NH:8][C:5]3[CH:6]=[CH:7][C:2]([CH3:1])=[CH:3][C:4]=3[NH:9][C:23](=[O:26])[C:24]=2[CH:12]=1参加物
4
反応条件
- 温度
- 110 °C
実験手順
A mixture of 4-methyl-1,2-phenylenediamine (0.1 mol) and 6-chloro isatoic anhydride (0.1 mol) in acetic acid (85%) was heated at 110° C. for 2 hrs. The mixture was poured into ice-cold water and 2-chloro-8-methyl-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-11-one was isolated (93%) after neutralisation and filtration.
後処理
- additionThe mixture was poured into ice-cold water
出典と根拠
- ORDレコード
- ord-54cc76e55d0f4c9294ad4d59f0331240
- 出典データセット
- uspto-grants-2012_06
- 特許番号
- US08202989B2
関連ノート
読み込み中…